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- S.C.A.R. - Squadra Corse Alfa Romeo Mobile
- S.C.A.R. - Squadra Corse Alfa Romeo PC
- S.C.A.R. - Squadra Corse Alfa Romeo PlayStation 2
- S.C.A.R. - Squadra Corse Alfa Romeo Xbox
- S.C.A.R.S. Nintendo 64
- S.C.A.R.S. PC
- S.C.A.R.S. PlayStation
- S.T.A.L.K.E.R.: Shadow of Chernobyl PC
- S.W.A.T. the Movie: 3D Game Mobile
- Sabotain PC
- Saboteur Atari 2600
- Sabre Ace: Conflict Over Korea PC
- Sabre Wulf Game Boy Advance
- Sabre Wulf Mobile
- Sacred Mobile
- Sacred PC
- Sacred Underworld PC
- Sacrifice PC
- Saddle Up: Time to Ride PC
- SaGa Frontier PlayStation
- SaGa Frontier II PlayStation
- Sahara PC
- Sahara PlayStation 2
- Sailors of the Sky PC
- Saiyuki: Journey West PlayStation
- Sakura Himenishiki Emaki (working title) PlayStation 2
- Sakura Taisen Dreamcast
- Sakura Taisen 3 PlayStation 2
- Sakura Taisen 4 PC
- Sakura Taisen 5: Saraba Itoshiki Hito Yo PlayStation 2
- Sakura Taisen Monogatari PlayStation 2
- Sakura Taisen V Episode 0: Arano no Samurai Musume PlayStation 2
- Sakura Taisen: Atsuki Chishio Ni PlayStation 2
- Salt Lake 2002 Game Boy Advance
- Salt Lake 2002 PC
- Salt Lake 2002 PlayStation 2
- Salvo PC
- Sam & Max Freelance Police PC
- Samba de Amigo Dreamcast
- Samba de Amigo ver. 2000 Dreamcast
- Sammy Sosa High Heat Baseball 2001 PC
- Sammy Sosa High Heat Baseball 2001 PlayStation
- Sammy Sosa Softball Slam PC
- Sammy Sosa's Softball Slam PlayStation
- Sammy vs. Capcom Arcade Games
- Samurai Evolution: Oukoku Geist Game Boy Advance
- Samurai Jack Game Boy Advance
- Samurai Jack: Samurai Showdown Mobile
- Samurai Jack: The Shadow of Aku GameCube
- Samurai Jack: The Shadow of Aku PlayStation 2
- Samurai Jack: The Shadow of Aku Xbox
- Samurai Shodown Mobile
- Samurai Shodown Neo-Geo CD
- Samurai Shodown II Neo-Geo CD
- Samurai Shodown III Neo-Geo CD
- Samurai Shodown III PlayStation
- Samurai Shodown V Arcade Games
- Samurai Shodown V Neo-Geo CD
- Samurai Shodown V PlayStation 2
- Samurai Shodown V Xbox
- Samurai Shodown V Special Arcade Games
- Samurai Shodown V Special Neo-Geo CD
- Samurai Shodown V Special PlayStation 2
- Samurai Shodown V Special Xbox
- Samurai Shodown! 2 NeoGeo Pocket Color
- Samurai Shodown: Warrior's Rage PlayStation
- Samurai Warriors PlayStation 2
- Samurai Warriors Xbox
- Samurai Warriors: Xtreme Legends PlayStation 2
- Samurai Western PlayStation 2
- San Francisco Rush Nintendo 64
- San Francisco Rush PlayStation
- San Francisco Rush 2049 Dreamcast
- San Francisco Rush 2049 Game Boy Color
- San Francisco Rush 2049 Nintendo 64
- San Goku Shi Taisen Arcade Games
- Sanctum PC
- Sandwarriors PC
- Sanitarium PC
- Sanity: Aiken's Artifact PC
- Santa Claus in Trouble PC
- Santa Fe Mysteries: The Elk Moon Murder PC
- SAS: Commando Mobile
- Saturday Night Speedway PC
- Saturday Night Speedway PlayStation 2
- Saturn Bomberman Saturn
- Saturn Bomberman Fight!! Saturn
- Savage Safari Hunt PlayStation 2
- Savage Safari Hunt Xbox
- Savage Skies PC
- Savage Skies PlayStation 2
- Savage: The Battle for Newerth PC
- Savage: The Ultimate Quest for Survival PC
- Save Leopards PC
- Scaler GameCube
- Scaler PlayStation 2
- Scaler Xbox
- Scandal PlayStation 2
- Scarab PC
- Scarface PC
- Scarface PlayStation 2
- Scarface Xbox
- Scarlet Waves PC
- Schizm PC
- School of Rock Audition Mobile
- School Tycoon PC
- Schoolyard Sports PC
- Sci-Fi Channel Trivia Game PC
- Scooby Doo! Classic Creep Capers Game Boy Color
- Scooby Doo! Classic Creep Capers Nintendo 64
- Scooby-Doo 2: Monsters Unleashed Game Boy Advance
- Scooby-Doo 2: Monsters Unleashed PC
- Scooby-Doo! Game Boy Advance
- Scooby-Doo! Mystery Mayhem GameCube
- Scooby-Doo! Mystery Mayhem PlayStation 2
- Scooby-Doo! Mystery Mayhem Xbox
- Scooby-Doo! Night of 100 Frights GameCube
- Scooby-Doo! Night of 100 Frights PlayStation 2
- Scooby-Doo! Night of 100 Frights Xbox
- Scooby-Doo! Unmasked DS
- Scooby-Doo! Unmasked Game Boy Advance
- Scooby-Doo! Unmasked GameCube
- Scooby-Doo! Unmasked PlayStation 2
- Scooby-Doo! Unmasked Xbox
- Scooby-Doo: Mystery Mayhem Game Boy Advance
- Scorched Planet PC
- Scorcher PC
- Scorcher Saturn
- Scrabble PC
- Scrabble PlayStation
- Scrabble Complete PC
- Scrabble Online PC
- Scrabble Rack Attack PC
- Scrapland PC
- Scrapland Xbox
- Screamer PC
- Screamer 2 PC
- Screamer 4x4 PC
- Scud: Industrial Evolution PC
- Scud: The Disposable Assassin Saturn
- SD Gundam Force Game Boy Advance
- SD Gundam Force PlayStation 2
- Sea Dogs PC
- Sea Dogs II Xbox
- Sea Legends PC
- Sea Trader: Rise of Taipan Game Boy Advance
- Sea Wolves PC
- SeaBlade Xbox
- Seal of Evil PC
- Seaman Dreamcast
- Seaman PlayStation 2
- Search and Rescue 2 PC
- Search and Rescue 3 PC
- Search and Rescue 4 PC
- Season Ticket Baseball PC
- Season Ticket Baseball 2003 PC
- Season Ticket Basketball 2003 PC
- Season Ticket Football 2003 PC
- SeaWorld Adventure Parks Tycoon PC
- SeaWorld Adventure Parks Tycoon 2 PC
- Second Life PC
- Second Sight GameCube
- Second Sight PC
- Second Sight PlayStation 2
- Second Sight Xbox
- Secret of the Silver Earring PC
- Secret Service: In Harm's Way PC
- Secret Service: Security Breach PC
- Secret Weapons Over Normandy PC
- Secret Weapons Over Normandy PlayStation 2
- Secret Weapons Over Normandy Xbox
- Seed PC
- Seek & Destroy PC
- Seek and Destroy PlayStation 2
- Sega Ages: After Burner II PlayStation 2
- Sega Ages: Decathlete Collection PlayStation 2
- Sega Ages: Fantasy Zone PlayStation 2
- Sega Ages: Fist of the North Star PlayStation 2
- Sega Ages: Gain Ground PlayStation 2
- Sega Ages: Monaco GP PlayStation 2
- Sega Ages: Outrun PlayStation 2
- Sega Ages: Phantasy Star: Generation 1 PlayStation 2
- Sega Ages: V.R. Virtua Racing PlayStation 2
- Sega Ages: Virtua Fighter 2 PlayStation 2
- Sega Arcade Gallery Game Boy Advance
- Sega Bass Fishing Dreamcast
- Sega Bass Fishing 2 Dreamcast
- Sega Bass Fishing Duel PlayStation 2
- Sega Classics Collection PlayStation 2
- Sega GT Dreamcast
- Sega GT 2002 Xbox
- Sega GT Online Xbox
- Sega Marine Fishing Dreamcast
- Sega Rally 2 Dreamcast
- Sega Rally 2 PC
- Sega Rally 2005 PlayStation 2
- Sega Rally Championship Game Boy Advance
- Sega Rally Championship N-Gage
- Sega Rally Championship PC
- Sega Smash Pack Game Boy Advance
- Sega Smash Pack Volume 1 Dreamcast
- Sega Soccer Slam GameCube
- Sega Soccer Slam PlayStation 2
- Sega Soccer Slam Xbox
- Sega Sports Tennis PlayStation 2
- Sega Super Monkey Ball Mobile
- Sega SuperStars PlayStation 2
- Sega Swirl PC
- Sega Touring Car Championship PC
- Sega Touring Car Championship Saturn
- Segagaga Dreamcast
- Seiken Densetsu 3 SNES
- Semper Fi PC
- Sengoku 2 Neo-Geo CD
- Sengoku Turb Dreamcast
- Sensible Soccer Mobile
- Sensible Soccer Sega Master System
- Sensible Soccer '98 PC
- Sentient PC
- Sentient PlayStation
- Sentinel Returns PC
- Sentinel Returns PlayStation
- Sentinel: Descendants in Time PC
- Septerra Core: Legacy of the Creator PC
- Seraphim PC
- Sergei Fedorov Face-Off Hockey Mobile
- Serious Sam Xbox
- Serious Sam 2 PC
- Serious Sam 2 Xbox
- Serious Sam Advance Game Boy Advance
- Serious Sam: Next Encounter GameCube
- Serious Sam: Next Encounter PlayStation 2
- Serious Sam: The First Encounter PC
- Serious Sam: The Second Encounter PC
- Settlers III: Quest of the Amazons PC
- Seven Games of the Soul PC
- Seven Kingdoms PC
- Seven Kingdoms II: The Fryhtan Wars PC
- Seven Kingdoms: Ancient Adversaries PC
- Seven Kingdoms: Conquest PC
- Seven Samurai 20XX PlayStation 2
- Seven: Molmorth no Kiheitai PlayStation 2
- Seventh Cross Evolution Dreamcast
- Sgt. Cruise GameCube
- Sgt. Rock: On the Frontline Game Boy Color
- Shade: Wrath of Angels N-Gage
- Shade: Wrath of Angels PC
- Shade: Wrath of Angels Xbox
- Shado Fighter Mobile
- Shadoan PC
- Shadow PC
- Shadow Company: Left For Dead PC
- Shadow Force: Razor Unit PC
- Shadow Hearts PlayStation 2
- Shadow Hearts: Covenant PlayStation 2
- Shadow Hearts: From the New World PlayStation 2
- Shadow Madness PlayStation
- Shadow Man Dreamcast
- Shadow Man Nintendo 64
- Shadow Man PC
- Shadow Man PlayStation
- Shadow Man: 2econd Coming PlayStation 2
- Shadow Master PC
- Shadow Master PlayStation
- Shadow of Destiny PC
- Shadow of Destiny PlayStation 2
- Shadow of Rome PlayStation 2
- Shadow of the Colossus PlayStation 2
- Shadow of the Sun PlayStation 2
- Shadow Ops: Red Mercury PC
- Shadow Ops: Red Mercury Xbox
- Shadow the Hedgehog GameCube
- Shadow the Hedgehog PlayStation 2
- Shadow Tower PlayStation
- Shadow Tower Abyss PlayStation 2
- Shadow Vault PC
- Shadow Warrior PC
- Shadow Watch PC
- Shadowbane Macintosh
- Shadowbane PC
- Shadowbane: The Rise of Chaos PC
- Shadowbane: Throne of Oblivion PC
- ShadowFlare PC
- Shadowgate 64: Trial of the Four Towers Nintendo 64
- Shadowgate Classic Game Boy Color
- Shadowgate Classic Mobile
- Shaft: Sharp Shooter Mobile
- Shaman PC
- Shaman King: Legacy of the Spirits, Soaring Hawk Game Boy Advance
- Shaman King: Legacy of the Spirits, Sprinting Wolf Game Boy Advance
- Shaman King: Master of Spirits Game Boy Advance
- Shaman King: Power of Spirit PlayStation 2
- Shanghai Dragon PC
- Shanghai Street Racer PC
- Shanghai: Dynasty PC
- Shanghai: Second Dynasty PC
- Shanghai: True Valor PlayStation
- Shannara PC
- Shantae Game Boy Color
- Shantae Advance Game Boy Advance
- Shark Hunt Mobile
- Shark Tale Game Boy Advance
- Shark Tale GameCube
- Shark Tale PC
- Shark Tale PlayStation 2
- Shark Tale Xbox
- Shark Tale Activity Center PC
- Shark! Hunting the Great White PC
- Shattered Galaxy PC
- Shattered Light PC
- Shattered Steel PC
- Shaun Palmer's Pro Snowboarder Game Boy Advance
- Shaun Palmer's Pro Snowboarder PlayStation 2
- Shaun Palmer's Pro Snowboarder 2 Game Boy Advance
- Shaun Palmer's Pro Snowboarder 2 GameCube
- Shaun Palmer's Pro Snowboarder 2 PlayStation 2
- Shaun Palmer's Pro Snowboarder 2 Xbox
- Shayde: Monsters vs. Humans Xbox
- She, the Ultimate Weapon PlayStation 2
- Sheep PC
- Sheep PlayStation
- Sheep Raider PlayStation
- Shellshock PC
- ShellShock: Nam '67 PC
- ShellShock: Nam '67 PlayStation 2
- ShellShock: Nam '67 Xbox
- Shenmue Dreamcast
- Shenmue II Dreamcast
- Shenmue II Xbox
- Shenmue Online PC
- Shifters PlayStation 2
- Shikigami no Shiro Xbox
- Shikigami no Shiro II PC
- Shikigami no Shiro II Xbox
- Shikigami no Shiro III Arcade Games
- Shin Megami Tensei DS DS
- Shin Megami Tensei Nine Xbox
- Shin Megami Tensei Online: Imagine PC
- Shin Megami Tensei: Devil Children Messiah Riser Game Boy Advance
- Shin Megami Tensei: Digital Devil Saga PlayStation 2
- Shin Megami Tensei: Nocturne PlayStation 2
- Shin Sangoku Musou Advance Game Boy Advance
- Shining Force III Saturn
- Shining Force III Scenario 2 Saturn
- Shining Force III Scenario 3 Saturn
- Shining Force NEO PlayStation 2
- Shining Force: Resurrection of the Dark Dragon Game Boy Advance
- Shining Lore Online PC
- Shining Soul Game Boy Advance
- Shining Soul II Game Boy Advance
- Shining Tears PlayStation 2
- Shining the Holy Ark Saturn
- Shinobi PlayStation 2
- Shinseiki Yuusha Taisen PlayStation 2
- Shinsengumi PlayStation 2
- Shinsengumi Gunrou-den PlayStation 2
- Shipwreckers! PC
- Shipwreckers! PlayStation
- Shiritsu Justice Gakuen Nekketsu Seisyun Nikki 2 PlayStation
- Shivers PC
- Shivers II: Harvest of Souls PC
- Shogo: Mobile Armor Division PC
- Shogun: Total War PC
- Shogun: Total War Warlord Edition PC
- Shoot to Kill: Colombian Crackdown GameCube
- Shoot to Kill: Colombian Crackdown PC
- Shot Online PC
- Showdown: Legends of Wrestling PlayStation 2
- Showdown: Legends of Wrestling Xbox
- Shox GameCube
- Shox PlayStation 2
- Shrak for Quake PC
- Shrapnel: Urban Warfare 2025 Dreamcast
- Shrek Xbox
- Shrek 2 Game Boy Advance
- Shrek 2 GameCube
- Shrek 2 Mobile
- Shrek 2 PC
- Shrek 2 PlayStation 2
- Shrek 2 Xbox
- Shrek 2: Beg for Mercy Game Boy Advance
- Shrek 2: Team Action PC
- Shrek Extra Large GameCube
- Shrek Game Land Activity Center PC
- Shrek Swamp Kart Speedway Game Boy Advance
- Shrek Treasure Hunt PlayStation
- Shrek: Fairy Tale Freakdown Game Boy Color
- Shrek: Reekin' Havoc Game Boy Advance
- Shrek: Super Party GameCube
- Shrek: Super Party PlayStation 2
- Shrek: Super Party Xbox
- Shutokou Battle 01 PlayStation 2
- Shutokou Battle: Zone of Control PlayStation Portable
- Siberian Strike Episode II Mobile
- Sid Meier's Alien Crossfire PC
- Sid Meier's Alpha Centauri PC
- Sid Meier's Antietam! PC
- Sid Meier's Civilization III: Complete PC
- Sid Meier's Gettysburg! PC
- Sid Meier's Pirates! PC
- Sid Meier's Pirates! Xbox
- Sid Meier's SimGolf PC
- Side Pocket for WonderSwan WonderSwan
- Siege of Avalon PC
- Sigma Star Saga Game Boy Advance
- Silent Bomber PlayStation
- Silent Hill PlayStation
- Silent Hill 2 PC
- Silent Hill 2 PlayStation 2
- Silent Hill 2: Restless Dreams PlayStation 2
- Silent Hill 2: Restless Dreams Xbox
- Silent Hill 3 PC
- Silent Hill 3 PlayStation 2
- Silent Hill 4: The Room PC
- Silent Hill 4: The Room PlayStation 2
- Silent Hill 4: The Room Xbox
- Silent Hunter PC
- Silent Hunter II PC
- Silent Hunter III PC
- Silent Line: Armored Core PlayStation 2
- Silent Scope Dreamcast
- Silent Scope Game Boy Advance
- Silent Scope PlayStation 2
- Silent Scope 2 PlayStation 2
- Silent Scope 3 PlayStation 2
- Silent Scope Complete Xbox
- Silent Storm PC
- Silent Storm: Sentinels PC
- Silent Thunder: A-10 Tank Killer II PC
- Silhouette Mirage PlayStation
- Silpheed: The Lost Planet PlayStation 2
- Silver Dreamcast
- Silver PC
- SimCity PC
- SimCity SNES
- SimCity 2000 Game Boy Advance
- SimCity 2000 PC
- SimCity 2000 PlayStation
- SimCity 2000: Network Edition PC
- SimCity 3000 PC
- SimCity 3000 Unlimited PC
- SimCity 4 PC
- SimCity 4: Deluxe Edition PC
- SimCity 4: Rush Hour PC
- SimCoaster PC
- SimCopter PC
- SimIsle: Missions in the Rainforest PC
- Simon Mobile
- Simon the Sorcerer 3D PC
- Simon the Sorceror PC
- Simon the Sorceror 2 PC
- SimPark PC
- Simpsons Skateboarding PlayStation 2
- SimSafari PC
- SimsVille PC
- SimTheme Park PC
- SiN PC
- Sin and Punishment: Successor of the Earth Nintendo 64
- Sin Mission Pack: Wages of Sin PC
- Sinbad: Legend of the Seven Seas PC
- Sing: Star Classics PlayStation 2
- Singles 2: Triple Trouble PC
- Singles: Flirt Up Your Life PC
- SingStar PlayStation 2
- SingStar Party PlayStation 2
- Sinistar: Unleashed PC
- Siren PlayStation 2
- Siren 2 PlayStation 2
- Sitting Ducks Game Boy Advance
- Sitting Ducks PC
- Sitting Ducks PlayStation 2
- Sitting Ducks Xbox
- SK8 PlayStation 2
- Skate & Slam Mobile
- Skate Park Tycoon PC
- Skateboard Park Tycoon Mobile
- Skateboard Park Tycoon 2004 PC
- Ski Jumping Mobile
- Ski Park Manager PC
- Ski Resort Extreme PC
- Ski Resort Tycoon PC
- Ski Resort Tycoon II PC
- Ski-Doo X-Team Racing PC
- Skies of Arcadia Dreamcast
- Skies of Arcadia PlayStation 2
- Skies of Arcadia Legends GameCube
- Skools Out PC
- Skout PC
- Skrap PC
- SkullCracker PC
- SkullMonkeys PlayStation
- Sky Captain: Flying Legion Air Combat Challenge PC
- Sky Diver Atari 2600
- Sky Gunner PlayStation 2
- Sky Odyssey PlayStation 2
- Skydive! PC
- SkyKnights of World War I: Dawn of Aces III PC
- SLAI: Phantom Crash PlayStation 2
- Slam Tennis Xbox
- Slamscape PC
- Slamscape PlayStation
- Slamtilt PC
- Slave Zero Dreamcast
- Slave Zero PC
- Sled Storm PlayStation
- Sled Storm PlayStation 2
- Slime Morimori Dragon Quest: Shougeki No Shippo Dan Game Boy Advance
- Slingo PC
- Sly 2: Band of Thieves PlayStation 2
- Sly Cooper and the Thievius Raccoonus PlayStation 2
- Slyder Mobile
- Small Soldiers PlayStation
- Smart Bomb PlayStation Portable
- Smart Games Challenge 3 PC
- Smart Games Word Puzzles PC
- Smash Cars PlayStation 2
- Smash Court 2 PlayStation
- Smash Court Tennis Pro Tournament PlayStation 2
- Smash Court Tennis Pro Tournament 2 PlayStation 2
- Smash TV Arcade Games
- Smash Up Derby PC
- Smashing Drive Game Boy Advance
- Smashing Drive GameCube
- Smashing Drive Xbox
- Smuggler's Run Game Boy Advance
- Smuggler's Run PlayStation 2
- Smuggler's Run 2: Hostile Territory PlayStation 2
- Smuggler's Run: Warzones GameCube
- Smurf Racer PlayStation
- Smurf's Nightmare Game Boy Color
- Snakes N-Gage
- Snapshot! Paparazzi PC
- Sneakers Xbox
- Sniper Elite: Berlin 1945 PC
- Sniper Elite: Berlin 1945 PlayStation 2
- Sniper Elite: Berlin 1945 Xbox
- Sniper: Path of Vengeance PC
- Sniper: Path of Vengeance Xbox
- SNK Gals' Fighters NeoGeo Pocket Color
- SNK vs. Capcom: Card Fighter's Clash - SNK Version NeoGeo Pocket Color
- SNK vs. Capcom: Match of the Millennium NeoGeo Pocket Color
- Sno-Cross Championship Racing Dreamcast
- Sno-Cross Championship Racing PlayStation
- Sno-Cross Racing Pro PC
- Snood Mobile
- Snoop Dogg Boxing Mobile
- Snowboard Kids 2 Nintendo 64
- Snowboard Park Tycoon PC
- Snowboards Kids DS DS
- Soccer Kid Game Boy Advance
- SOCOM 3: U.S. Navy SEALs PlayStation 2
- SOCOM II: U.S. Navy SEALs PlayStation 2
- SOCOM: U.S. Navy SEALs PlayStation 2
- SODA Off-Road Racing PC
- Soda Pipes PC
- Sol Divide Saturn
- Solar: Campaigns PC
- Solaris Atari 2600
- Soldat PC
- Soldier PC
- Soldier Ants Mobile
- Soldier Boyz PC
- Soldier of Fortune Dreamcast
- Soldier of Fortune PC
- Soldier of Fortune Gold PlayStation 2
- Soldier of Fortune II: Double Helix PC
- Soldier of Fortune II: Double Helix Xbox
- Soldier of Fortune II: Gold PC
- Soldiers at War PC
- Soldiers of Anarchy PC
- Soldiers: Heroes of World War II PC
- Soldner: Marine Corps PC
- Soldner: Secret Wars PC
- Sole Predator PlayStation 2
- Sole Predator Xbox
- Solid Balance PC
- Solid Ice PC
- Solitaire 4 Pack Mobile
- Solitaire XP Championship PC
- Solomon Game Boy Color
- Solomon's Key NES
- Son of the Mask Mobile
- Sonic 3D Blast PC
- Sonic 3D Blast Saturn
- Sonic Advance Game Boy Advance
- Sonic Advance 2 Game Boy Advance
- Sonic Advance 3 Game Boy Advance
- Sonic Adventure Dreamcast
- Sonic Adventure 2 Dreamcast
- Sonic Adventure 2 Battle GameCube
- Sonic Adventure DX Director's Cut GameCube
- Sonic Adventure DX Director's Cut PC
- Sonic Battle Game Boy Advance
- Sonic CD PC
- Sonic DS (working title) DS
- Sonic Heroes GameCube
- Sonic Heroes PC
- Sonic Heroes PlayStation 2
- Sonic Heroes Xbox
- Sonic Jam Saturn
- Sonic Mega Collection GameCube
- Sonic Mega Collection Plus PlayStation 2
- Sonic Mega Collection Plus Xbox
- Sonic Pinball Party Game Boy Advance
- Sonic R Saturn
- Sonic Shuffle Dreamcast
- Sonic the Hedgehog Genesis
- Sonic The Hedgehog: Pocket Adventure NeoGeo Pocket Color
- Sonic X: Game Boy Advance Video Volume 1 Game Boy Advance
- SonicN N-Gage
- Sorcerian Dreamcast
- Sorry! PC
- Soukaigi PlayStation
- Soukyugurentai Saturn
- Soul Blade PlayStation
- Soul Calibur Dreamcast
- Soul Calibur II Arcade Games
- Soul Calibur II GameCube
- Soul Calibur II PlayStation 2
- Soul Calibur II Xbox
- Soul Fighter Dreamcast
- Soul of the Samurai PlayStation
- Soul Reaver 2 Dreamcast
- Soul Reaver 2 PC
- Soul Reaver 2 PlayStation 2
- Soulbringer PC
- SoulTrap PC
- South Park Mobile
- South Park Nintendo 64
- South Park PC
- South Park PlayStation
- South Park Rally Dreamcast
- South Park Rally Nintendo 64
- South Park Rally PlayStation
- South Park Rally - PC PC
- South Park: Chef's Luv Shack Dreamcast
- South Park: Chef's Luv Shack Nintendo 64
- South Park: Chef's Luv Shack PC
- South Park: Chef's Luv Shack PlayStation
- Sovereign PC
- Soviet Strike PlayStation
- Space Bunnies Must Die! PC
- Space Channel 5 Dreamcast
- Space Channel 5 PlayStation 2
- Space Channel 5 Part 2 Dreamcast
- Space Channel 5 Special Edition PlayStation 2
- Space Channel 5: Ulala's Cosmic Attack Game Boy Advance
- Space Colony PC
- Space Empires: IV PC
- Space Empires: IV Gold PC
- Space Empires: Starfury PC
- Space Fishermen PlayStation 2
- Space Haste 2 PC
- Space HoRSE PC
- Space Interceptor: Project Freedom PC
- Space Invaders Nintendo 64
- Space Invaders '95 PC
- Space Invaders (Japan) PlayStation
- Space Invaders Anniversary PlayStation 2
- Space Invaders Collection Colecovision
- Space Invaders: Invasion Day PlayStation 2
- Space Jam PlayStation
- Space Raiders GameCube
- Space Rangers PC
- Space Rangers 2: Dominators PC
- Space Station Manager PC
- Space Station Silicon Valley Nintendo 64
- Space Taxi 2 PC
- Spaceward Ho! IV PC
- Spartan PC
- Spartan: Total Warrior GameCube
- Spartan: Total Warrior PlayStation 2
- Spartan: Total Warrior Xbox
- Spawn the Eternal PlayStation
- Spawn: Armageddon GameCube
- Spawn: Armageddon PlayStation 2
- Spawn: Armageddon Xbox
- Spawn: In the Demon's Hand Dreamcast
- Spearhead PC
- Spec Ops II: Green Berets PC
- Spec Ops: Omega Squad Dreamcast
- Spec Ops: Ranger Elite PlayStation
- Spec Ops: Ranger Team Bravo PC
- Spec Ops: Rangers Lead the Way PC
- Spec Ops: Stealth Patrol PlayStation
- SpecForce PC
- Specnaz: Project Wolf PC
- Speed Busters: American Highways PC
- Speed Chaser 3D Mobile
- Speed Devils Dreamcast
- Speed Devils Mobile
- Speed Devils Online Racing Dreamcast
- Speed Kings GameCube
- Speed Kings PlayStation 2
- Speed Kings Xbox
- Speed Power Gunbike PlayStation
- Speed Punks PlayStation
- Speed Racer PlayStation
- Speedball 2100 PlayStation
- Speedball 2: Brutal Deluxe Game Boy Advance
- Speedball Arena PC
- Spellbinder: The Nexus Conflict PC
- SpellForce: Shadow of the Phoenix PC
- SpellForce: The Breath of Winter PC
- SpellForce: The Order of Dawn PC
- Spells of Gold PC
- Sphere PC
- Sphinx and the Cursed Mummy GameCube
- Sphinx and the Cursed Mummy PlayStation 2
- Sphinx and the Cursed Mummy Xbox
- Spice World PlayStation
- Spider-Man Dreamcast
- Spider-Man Game Boy Color
- Spider-Man Mobile
- Spider-Man Nintendo 64
- Spider-Man PC
- Spider-Man PlayStation
- Spider-Man 2 DS
- Spider-Man 2 Game Boy
- Spider-Man 2 Game Boy Advance
- Spider-Man 2 GameCube
- Spider-Man 2 N-Gage
- Spider-Man 2 PC
- Spider-Man 2 PlayStation 2
- Spider-Man 2 PlayStation Portable
- Spider-Man 2 Xbox
- Spider-Man 2 3D: NY Rooftops Mobile
- Spider-Man 2 Activity Center PC
- Spider-Man 2 Enter: Electro PlayStation
- Spider-Man 2: Enter the Sinister Six Game Boy Color
- Spider-Man and Friends PC
- Spider-Man vs. Doc Ock Mobile
- Spider-Man: Mysterio's Menace Game Boy Advance
- Spider-Man: The Movie Game Boy Advance
- Spider-Man: The Movie GameCube
- Spider-Man: The Movie PC
- Spider-Man: The Movie PlayStation 2
- Spider-Man: The Movie Xbox
- Spider: The Video Game PlayStation
- Spikeout Battle Street Xbox
- Spin Busta PC
- Spin Jam PlayStation
- Spirit of Speed 1937 Dreamcast
- Spirits & Spells Game Boy Advance
- Spirits & Spells GameCube
- Splashdown PlayStation 2
- Splashdown Xbox
- Splashdown: Riders Gone Wild Mobile
- Splashdown: Riders Gone Wild PlayStation 2
- Splinter Cell Pandora Tomorrow Mobile
- Spoils of War PC
- SpongeBob SquarePants (working title) Xbox
- SpongeBob SquarePants Bowling Mobile
- SpongeBob SquarePants Darts Mobile
- SpongeBob SquarePants: Battle for Bikini Bottom Game Boy Advance
- SpongeBob SquarePants: Battle for Bikini Bottom GameCube
- SpongeBob SquarePants: Battle for Bikini Bottom PC
- SpongeBob SquarePants: Battle for Bikini Bottom PlayStation 2
- SpongeBob SquarePants: Battle for Bikini Bottom Xbox
- SpongeBob SquarePants: Game Boy Advance Video Volume 1 Game Boy Advance
- SpongeBob SquarePants: Game Boy Advance Video Volume 2 Game Boy Advance
- SpongeBob SquarePants: Krusty Kollection PC
- SpongeBob SquarePants: Legend of the Lost Spatula Game Boy Color
- SpongeBob Squarepants: Revenge of the Flying Dutchman Game Boy Advance
- SpongeBob Squarepants: Revenge of the Flying Dutchman GameCube
- SpongeBob Squarepants: Revenge of the Flying Dutchman PlayStation 2
- SpongeBob SquarePants: SuperSponge Game Boy Advance
- SpongeBob SquarePants: The Movie Game Boy Advance
- SpongeBob SquarePants: The Movie GameCube
- SpongeBob SquarePants: The Movie Mobile
- SpongeBob SquarePants: The Movie PC
- SpongeBob SquarePants: The Movie PlayStation 2
- SpongeBob SquarePants: The Movie Xbox
- Spooks PC
- Spooks PlayStation 2
- Spooks Xbox
- Spore PC
- Sports Car GT PC
- Sports Car GT PlayStation
- Sports Illustrated 2005 Football Trivia Mobile
- Sports Illustrated for Kids: Baseball Game Boy Advance
- Spot Goes to Hollywood PlayStation
- SPQR: The Empire's Darkest Hour PC
- Spring Break PC
- Sprintmaster Atari 2600
- Sprung DS
- Spy Fiction PlayStation 2
- Spy Hunter Game Boy Advance
- Spy Hunter GameCube
- Spy Hunter Mobile
- Spy Hunter PC
- Spy Hunter PlayStation 2
- Spy Hunter Xbox
- Spy Hunter 2 GameCube
- Spy Hunter 2 PlayStation 2
- Spy Hunter 2 Xbox
- Spy Hunter 3 (working title) PlayStation 2
- Spy Hunter 3 (working title) Xbox
- Spy Kids 3-D: Game Over Game Boy Advance
- Spy Kids 3-D: Game Over PC
- Spy vs. Spy Game Boy Color
- Spy vs. Spy PlayStation 2
- Spy vs. Spy Xbox
- Spycraft: The Great Game PC
- Spyro 2: Ripto's Rage! PlayStation
- Spyro 2: Season of Flame Game Boy Advance
- Spyro Orange: The Cortex Conspiracy Game Boy Advance
- Spyro Ripto Quest Mobile
- Spyro the Dragon PlayStation
- Spyro: A Hero's Tail GameCube
- Spyro: A Hero's Tail PlayStation 2
- Spyro: A Hero's Tail Xbox
- Spyro: Attack of the Rhynocs Game Boy Advance
- Spyro: Enter the Dragonfly GameCube
- Spyro: Enter the Dragonfly PlayStation 2
- Spyro: Season of Ice Game Boy Advance
- Spyro: Year of the Dragon PlayStation
- Squad Assault (working title) Xbox
- Squad Assault: Operation Market Garden PC
- Squad Assault: West Front PC
- Squad Battles: Vietnam PC
- Squad Leader PC
- SSX PlayStation 2
- SSX 3 Game Boy Advance
- SSX 3 GameCube